
C 87
CAS No. 332420-90-3
C 87 ( —— )
产品货号. M26637 CAS No. 332420-90-3
C 87 是一种小分子 TNF-α 抑制剂。 C 87 直接与 TNFα 结合,有效抑制 TNF-α 诱导的细胞毒性 (IC50 = 8.73 μM),并有效阻断 TNF-α 触发的信号传导活动。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥478 | 有现货 |
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5MG | ¥786 | 有现货 |
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10MG | ¥1191 | 有现货 |
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25MG | ¥2406 | 有现货 |
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50MG | ¥4439 | 有现货 |
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100MG | ¥6391 | 有现货 |
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200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称C 87
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述C 87 是一种小分子 TNF-α 抑制剂。 C 87 直接与 TNFα 结合,有效抑制 TNF-α 诱导的细胞毒性 (IC50 = 8.73 μM),并有效阻断 TNF-α 触发的信号传导活动。
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产品描述C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.(In Vitro):C 87 reduces the activity of c-Jun N-terminal kinase (JNK) in L929 cells. C 87 prevents the degradation of IκBα in cells treated with TNF-α and potently blocks multiple signaling transduction pathways and downstream target gene activation triggered by TNF-α. C 87 exhibits good solubility and consistent dose-dependent functions in vitro. C 87 completely blocks the TNFα-induced activation of caspase-3 and caspase-8.(In Vivo):In mice, the level of alanine transaminase and aspartate transaminase is consistently reduced. C 87 markedly reduces injuries to the liver and improves animal survival. C 87 injection delays the incidence of death and increases the survival rate by two folds compared with the vehicle control.
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体外实验——
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number332420-90-3
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分子量502.93
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分子式C24H15ClN6O3S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 5.05 mg/mL (10.04 mM)
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SMILES[O-][N+](=O)c1cc(N\N=C2\C(=O)N(N=C2c2ccccc2)c2nc(cs2)-c2ccccc2)ccc1Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.J.C, del, R??o, et al. Py–GC/MS study of Eucalyptus globulus wood treated with different fungi[J]. Journal of Analytical and Applied Pyrolysis, 2001.
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